解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:STUDY OBJECTIVES:To assess the effectiveness of pretreatment with ibuprofen or acetaminophen compared with no pretreatment in decreasing adverse events in children and adolescents receiving the first and second series of pamidronate therapy; and to compare the effectiveness of ibuprofen versus acetaminophen for prevent...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.24.2.195.33143
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:To review the literature on clonidine, venlafaxine, selective serotonin reuptake inhibitors, and gabapentin for the treatment of hot flashes. DATA SOURCES:A MEDLINE search (January 1966-July 2003) was conducted to identify English-language literature available on the treatment of hot flashes that focused on ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.24.1.79.34812
更新日期:2004-01-01 00:00:00
abstract::Anemia is an undertreated but common complication of cancer and is associated with debilitating symptoms that impair the patient's ability to perform daily functions of life. Treatment with darbepoetin alfa, a novel erythropoiesis-stimulating protein, is appropriate for chemotherapy-induced anemia. Guidelines on darbe...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.16.110s.31970
更新日期:2003-12-01 00:00:00
abstract:STUDY OBJECTIVE:To quantify the relative risk of cardiovascular events associated with microalbuminuria in patients with both diabetes mellitus and hypertension. DESIGN:A structured literature search from January 1990-December 2002 using MEDLINE, IPA, and CINAHL. MEASUREMENTS AND MAIN RESULTS:We identified original s...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.23.15.1611.31962
更新日期:2003-12-01 00:00:00
abstract:STUDY OBJECTIVE:To establish the clinical equivalence (noninferiority) of one tablet containing abacavir 300 mg-lamivudine 150 mg-zidovudine 300 mg (Trizivir) versus a tablet containing lamivudine 150 mg-zidovudine 300 mg (Combivir) given with one abacavir (ABC) 300-mg tablet, administered twice/day, in antiretroviral-...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1592/phco.23.14.1432.31944
更新日期:2003-11-01 00:00:00
abstract::The field of acid suppression has been advanced by therapeutics of increasing specificity for inhibiting gastric acid secretion. Particularly important are proton pump inhibitors (PPIs), which inhibit the activity of the gastric acid pump (H+,K(+)-adenosine triphosphatase), the final common step in gastric acid produc...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.23.13.68s.31931
更新日期:2003-10-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the microbiologic and clinical outcomes of patients with extended-spectrum beta-lactamase (ESBL)-producing isolates over a 2-year period. DESIGN:Retrospective analysis. SETTING:Tertiary care teaching hospital. PATIENTS:Twenty-one patients with cultures of confirmed ESBL-producing Escheric...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.12.1232.32706
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:The bispectral index (BIS), a processed variable derived from the raw electroencephalogram (EEG) used to guide sedation in the intensive care unit (ICU), has not been tested during barbiturate therapy for elevated intracranial pressure. We determined the BIS and suppression ratio (SR) values during traditiona...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.10.1087.32766
更新日期:2003-09-01 00:00:00
abstract::A 23-year-old man was brought to the emergency department after eating four boxes of brodifacoum-containing rodenticide over a 4-day interval and pieces from approximately two bottles of glass over the previous 2 weeks. He was asymptomatic but his prothrombin time was markedly elevated with an international normalized...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.10.1186.32755
更新日期:2003-09-01 00:00:00
abstract::This study compared limited sampling methods (LSM) of estimating area under the plasma concentration versus time curve (AUC) based on a Bayesian regularized neural network, the Bayesian approach, and multiple forward stepwise regression models from selected concentration-time points. Plasma concentration versus time d...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.8.1044.32872
更新日期:2003-08-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if milk thistle (silymarin) alters the pharmacokinetics of indinavir. DESIGN:Sequential crossover trial. SETTING:General clinical research center. SUBJECTS:Ten healthy subjects. INTERVENTION:Indinavir 800 mg 3 times/day was given for four doses on days 1 and 2. Silymarin 160 mg 3 times/...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.23.7.866.32723
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:As tenofovir disoproxil fumarate substantially increases plasma concentrations of didanosine in patients with human immunodeficiency virus-1 infection, we sought to determine whether tenofovir and didanosine showed a similar intracellular interaction in human peripheral blood mononuclear cells (PBMCs). DESIG...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.6.695.32189
更新日期:2003-06-01 00:00:00
abstract::Posttransplantation hypertension has been identified as an independent risk factor for chronic allograft dysfunction and loss. Based on available morbidity and mortality data, posttransplantation hypertension must be identified and managed appropriately. During the past decade, calcium channel blockers have been recom...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.23.6.788.32180
更新日期:2003-06-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the toxicity of amphotericin B deoxycholate formulations. DESIGN:In vitro experiment. SETTING:University research center. MATERIAL:Human mononuclear THP-1 cells. INTERVENTION:The human mononuclear cells were exposed in vitro for 2 hours to the following deoxycholate formulations of ampho...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.5.572.32209
更新日期:2003-05-01 00:00:00
abstract:STUDY OBJECTIVE:To determine prescribing patterns and clinical outcomes of enoxaparin for anticoagulation of atrial fibrillation. DESIGN:Retrospective analysis. SETTING:A 650-bed, tertiary care, community teaching hospital. SUBJECTS:Two hundred thirteen patients who received enoxaparin for thromboprophylaxis during ...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.23.5.651.32208
更新日期:2003-05-01 00:00:00
abstract::Starting lipid-lowering therapy in the hospital, especially with statins, has become an important component in the management of patients with acute coronary syndromes (ACS). It improves outcomes and increases patient motivation and long-term adherence. In addition, discontinuation of statin therapy in patients with A...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.23.4.506.32129
更新日期:2003-04-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the effects of food on the bioavailability of testosterone undecanoate, testosterone, and 5alpha-dihydrotestosterone (DHT) after administration of a new oral testosterone undecanoate formulation, Andriol Testocaps. DESIGN:Randomized, open-label, crossover study with a 1-week washout period. ...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.23.3.319.32104
更新日期:2003-03-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the efficacy of reteplase administration in clearing hemodialysis catheters. DESIGN:Open-label, uncontrolled, observational trial. SETTING:University medical center. PATIENTS:Thirty-four patients with end-stage renal disease undergoing long-term hemodialysis. INTERVENTION:Patients had du...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.23.2.137.32086
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To compare the effectiveness of an evidence-based, systematic approach to hypertension care involving comanagement of patients by primary care physicians and clinical pharmacists versus usual care in reducing blood pressure in patients with uncontrolled hypertension. METHODS:Patients in a staff model medical...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.23.2.209.32096
更新日期:2003-02-01 00:00:00
abstract::Atrial fibrillation is the most common sustained cardiac arrhythmia and is associated with thromboembolic events and hemodynamic impairment that results in considerable morbidity, mortality, and cost. Cardioversion to sinus rhythm is a common approach to the treatment of these patients. However, cardioversion is assoc...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.23.1.57.31917
更新日期:2003-01-01 00:00:00
abstract::We sought to summarize and assess original evaluations of the economic impact of clinical pharmacy services published from 1996-2000, and to provide recommendations and methodologic considerations for future research. A systematic literature search was conducted to identify articles that were then blinded and randomly...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.23.1.113.31910
更新日期:2003-01-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the ability of seven widely known herbal references and electronic databases to answer questions about herbal products asked at drug information centers. DESIGN:Cross-sectional study. SETTING:Five academic and institutional drug information centers. METHODS:Fifty-seven herbal-related ques...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.22.17.1611.34126
更新日期:2002-12-01 00:00:00
abstract::Fatigue is one of the most debilitating and common symptoms associated with hematologic and oncologic disorders and treatment strategies. Patient factors influence etiology and symptom manifestation, which in turn affect diagnosis, management, and monitoring. Fatigue instruments can assist with the identification, man...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.22.16.1433.33690
更新日期:2002-11-01 00:00:00
abstract::A 40-year-old Caucasian man diagnosed with right deep venous thrombosis secondary to trauma was treated with subcutaneous enoxaparin. Within minutes of administering the first dose (1 mg/kg), he experienced an apparent anaphylactoid reaction; symptoms were abdominal pruritus, severe cough, shortness of breath, anxiety...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.22.16.1511.33688
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of telephone follow-up on the physical well-being dimension of health-related quality of life in patients with cancer. DESIGN:Randomized, controlled trial. SETTING:Public teaching hospital. PATIENTS:One hundred fifty patients with cancer who were discharged to home from the hospital....
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.22.15.1301.33480
更新日期:2002-10-01 00:00:00
abstract::Sepsis and acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are associated with high mortality rates despite recent therapeutic advances. Both disease states involve uncontrolled host defense responses that lead to inflammation, endothelial damage, enhanced coagulation, diminished fibrinolysis and...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.22.13.1140.33519
更新日期:2002-09-01 00:00:00
abstract::A 64-year-old woman receiving intravenous chemotherapy for stage IIIB non-small cell lung cancer experienced acute arterial thrombosis of the distal radial and entire ulnar arteries with subsequent arterial occlusion of the right popliteal artery. Two separate arterial occlusions occurred after administration of cispl...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.22.13.1200.33524
更新日期:2002-09-01 00:00:00
abstract:STUDY OBJECTIVE:To quantify Asian and Asian-American college students' knowledge of osteoporosis and preventive health behaviors. DESIGN:Sixty-four-question survey SETTING:University of Minnesota. SUBJECTS:One hundred sixty-eight male and female Asian and Asian-American students, mean age 21 +/- 3.4 years. MAIN RES...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.22.12.1047.33608
更新日期:2002-08-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the safety and efficacy of aerosolized ceftazidime for prevention of ventilator-associated pneumonia (VAP) and to evaluate the effects of the drug on the proinflammatory response. DESIGN:Prospective, randomized, double-blind, placebo-controlled clinical trial. SETTING:University teaching ...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.22.12.972.33596
更新日期:2002-08-01 00:00:00
abstract::Patients with ST-segment elevation acute myocardial infarction require immediate reperfusion therapy. Reperfusion therapy can be provided by either pharmacologic or mechanical means. Pharmacologic reperfusion therapy consists of administering fibrinolytics, whereas mechanical reperfusion consists of performing percuta...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.22.11.864.33632
更新日期:2002-07-01 00:00:00
abstract::Thrombin, a serine protease, is the keystone of the twin processes of hemostasis and thrombosis. Through procoagulant, anticoagulant, and antifibrinolytic mechanisms, thrombin helps maintain vascular integrity in the face of hemorrhage. These same mechanisms, however, allow for the pathologic formation of thrombi in r...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.22.10.90s.33617
更新日期:2002-06-01 00:00:00
abstract:STUDY OBJECTIVE:To determine rates of drug-induced, rare, serious adverse events affecting the liver, kidneys, skin, or blood, occurring within 45 days of completing a prescription or refill for itraconazole or fluconazole. DESIGN:Population-based follow-up study SETTING:United Kingdom-based General Practice Research...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.22.9.697.34072
更新日期:2002-06-01 00:00:00
abstract::A 58-year-old man experienced an asthma exacerbation after administration of nicotine nasal spray for smoking cessation. His medical history was significant for asthma, chronic obstructive pulmonary disease, hypertension, and tobacco use when he was prescribed nicotine nasal spray for smoking cessation in an outpatien...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.22.9.779.34069
更新日期:2002-06-01 00:00:00
abstract::A literature search was conducted to examine the safety and effectiveness of low-dosage methotrexate for treatment and maintenance of remission in patients with inflammatory bowel disease. Nine published articles indicated that for patients with Crohn's disease, oral or intramuscular methotrexate 20-25 mg/week is safe...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.22.8.613.33208
更新日期:2002-05-01 00:00:00
abstract::Recent attention has been called to the interpretation of studies of antiinfective agents demonstrating effects on the QTc interval. It seems that the effects of many of these agents on the QTc interval are small, but in some patient populations, these drugs may cause morbidity and mortality related to TdP. It would b...
journal_title:Pharmacotherapy
pub_type: 评论,杂志文章
doi:10.1592/phco.22.8.663.33201
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To compare changes in United States pharmacy practice faculty demographics from 1995-2001 and to discuss the implications for junior faculty development. METHODS:Demographic data were extracted from the American Association of Colleges of Pharmacy institutional research system for academic years 1995-1996 an...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.22.7.445.33678
更新日期:2002-04-01 00:00:00
abstract::3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a frequently prescribed class of drugs that are generally well tolerated by most patients. A rare, yet serious side effect associated with these drugs is rhabdomyolysis. Although all HMG-CoA reductase inhibitors can cause this adverse effect, pre...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.22.7.533.33674
更新日期:2002-04-01 00:00:00
abstract::Ongoing improvements in immunosuppression and posttransplantation care have dramatically improved patient and graft outcomes after transplantation. The frequency of graft loss due to acute rejection has declined considerably as a result of the availability of a variety of more potent immunosuppressive agents and proba...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.22.5.316.33198
更新日期:2002-03-01 00:00:00
abstract::Cystic fibrosis affects 1/2500 individuals and is the most common lethal autosomal recessive disease in people of northern European descent. It is characterized by chronic infections with mucoid Pseudomonas aeruginosa and progressive deterioration of respiratory function. Much research has focused on the inflammatory ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.22.3.227.33544
更新日期:2002-02-01 00:00:00
abstract::Gram-negative septicemia due to central venous catheter-related infection is a leading cause of mortality and morbidity among patients who undergo hemodialysis. Antibiotic-heparin locks are valuable for preserving access sites and lowering the cost and inconvenience associated with central venous catheter replacement ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.22.1.105.33507
更新日期:2002-01-01 00:00:00